Games with the lowest house edge offer the best chances to win. Top choices include:
Blackjack (house edge ~0.5% with basic strategy)
Baccarat (banker bet house edge ~1.06%)
Video Poker (e.g., Jacks or Better with full pay)
Craps (certain bets like Pass Line with odds)
Slots can also pay big, especially progressive jackpots, but they typically have a higher house edge.